A Fatal Case Of Histiocytoid Sweets Syndrome And Myelodysplasia Unresponsive To Steroid Treatment: A Case And Review Of The Literature

We describe a fatal case of histiocytoid Sweet’s syndrome in a patient with myelodysplasia that was refractory to multiple therapies, including steroids. Though corticosteroids are classically the initial treatment for Sweet’s syndrome, other factors should be considered. Pat ients wi th concurrent myelodysplastic syndrome (MDS), or other hematologic malignancies, are often unresponsive to conventional therapies. We discuss the range of treatment options and importance of the initiation of alternative therapies early in the course of a patient with Sweet’s syndrome who is becoming increasingly resistant to steroids.